Min kuutortoo ko cookiiji ngam moƴƴinde humpito maa. So a jokkii ƴeewtaade lowre ndee, a jaɓii huutoraade kuukiiji amen. Kabaaruuji goɗɗi.
So a ɓuuɓtii “Accu fof”, a jaɓii mooftude kuukiiji e kaɓirgol maa ngam moƴƴinde naatgol lowre ndee, ƴeewtaade kuutoragol lowre ndee, e wallitde rokkude amen geɗe ganndal ɗe njoɓaaka, udditaaɗe. Kabaaruuji goɗɗi.
Mbele ƴeewndo ƴiiƴam hoyre mum ina waawi yiytude ñawu Alzheimer e nder daawal gadanal, ina addana ɗum en waɗde porogaraamuuji ƴeewndorɗe keewɗe ? Wiɗto keso wiyeteengo Frontiers in Aging Neuroscience ina hollita ɗum no feewi. Wiɗtooɓe ɓee ƴeewtindiima fedde mawnde ñawɓe Alzheimer, ɓe teddeendi mum en ina seerti e yimɓe celluɓe, ɓe nganndu-ɗaa ko kam en ngoni no haanirta nii, ngam anndude ceertugol biomarkers urine.
Ɓe tawi ko asid formik e nder ƴiiƴam ko maande teskinnde e ŋakkeende hakkille, ina waawi kadi hollitde ñawu Alzheimer gadano. Laabi gonɗi ngam anndude ñawu Alzheimer ina keewi, ina ŋakki, tee ina mbaawi ƴeewteede no haanirta nii. Ɗum firti ko ko ɓuri heewde e ñawɓe ina njiytee tan ko nde ɓe keɓata safaara moƴƴo. Kono tan, ƴeewndo ƴiiƴam ngo alaa ko nafata, ngo soodaani, ngo weeɓaani, ngam ƴeewde so tawii ko asid formik, ina waawi wonde ko safrooɓe ɓee naamnii ngam ƴeewndaade ko yaawi.
« Ñawu Alzheimer ko ñawu nguu ina jokki, ina waawi kadi jogaade duuɓi keewɗi hade mum feeñde e ŋakkeende hakkille » , mbiyi winndooɓe ɓee. "Daawe gadane ñawu nguu ina mbaɗa ko adii daawe ŋakkere hakkille ɗe mbaylaaka, ko ɗum woni windo kaŋŋe ngam naatde e safrude. Ko ɗum waɗi ƴeewndo mawngo ngam anndude ñawu Alzheimer gadano e nder mawɓe ina foti waɗde."
So tawii noon, so tawii ko yaawi ina waɗi nafoore, hol ko waɗi en ngalaa porogaraamuuji ƴeewndorɗe jowitiiɗe e ñawu Alzheimer e nder daawal gadanal ? Caɗeele ɗee ko e laabi ƴeewndo ɗi safrooɓe kuutortoo hannde ɗii. Ina jeyaa e ɗeen : tomogaraafi (tomographie émission positron) e ngaandi, ko huunde nde alaa ko nafata, tee ina addana ñawɓe radiis. Ina woodi kadi ƴeewndorɗe biomarker baawɗe yiytude Alzheimer, kono ina ɗaɓɓi ƴettugol ƴiiƴam walla ɓuuɓri ƴiiƴam ngam heɓde ƴiiƴam ɓalndu, tawi ñawɓe ina mbaawi jokkude.
Kono tan, ƴeewndorɗe ƴiiƴam ɗee ngonaa ko ustata, ina moƴƴi, ɗum noon ina moƴƴi e ƴeewndorɗe keewɗe. Hay so tawii wiɗtooɓe ɓee ina nganndi ko adii ɗuum biomarkeruuji ƴiiƴam ngam anndude ñawu Alzheimer, hay heen gootal ina moƴƴi e yiytude tolnooji gadani ñawu nguu, ɗum firti ko windo kaŋŋe ngam safrude ɗum ko yaawi ina heddii e ŋakkude.
Wiɗtooɓe wonɓe caggal wiɗto keso ngoo, ko adii ɗuum, njanngii ko huunde wiyeteende formaldehyde, ko wayi no biomarker urine ngam ñawu Alzheimer. Kono tan, ina woodi ɗo ɓeydata e yiytude ñawu nguu ko yaawi. E nder ndeeɗoo wiɗto sakkitiingo, ɓe mbaɗti heen hakkillaaji maɓɓe ko e formaat, woni mbaydi mbayliigu formaldehiid, ngam ƴeewde so tawii ina ɓuri moƴƴude e biomarker.
Ko ina tolnoo e 574 neɗɗo tawtoraama wiɗto ngoo, tawi tawtoraaɓe ɓee ko yimɓe wallitooɓe celluɓe e hakkillaaji mum en, walla ina njogii tolnooji keewɗi e yahrude yeeso ñawu nguu, gila e ŋakkeende hakkille (subjective cognitive decline) haa e ñawu nguu timmungu. Wiɗtooɓe ɓee ƴeewtindiima ƴiiƴam e ƴiiƴam tawtoraaɓe ɓee, mbaɗi heen ƴeewndo hakkille.
Wiɗto ngoo hollitii wonde tolno asid formik e nder ƴiiƴam ina ɓeydoo no feewi e nder denndaangal pelle ñawu Alzheimer, ina jokkondiri e ŋakkeende hakkille so renndinaama e ƴeewndorɗe celluɗe, haa arti noon e fedde ŋakkeende hakkille subjective adannde. Ɗum ina hollita wonde asid formik ina waawi wonde biomarker sensible wonande ñawu Alzheimer gadano.
Ko ɓuri haawnaade heen, nde wiɗtooɓe ɓee ƴeewtindii tolno formate e nder ƴiiƴam tawa ina yahdi e biomarkeruuji ƴiiƴam Alzheimer, ɓe tawi ina mbaawi ɓurde laaɓtude e tolno ñawu nguu ñawɗo oo rewata. Kono tan, wiɗtooji goɗɗi ina poti waɗeede ngam faamde jokkondire hakkunde ñawu Alzheimer e asid formik.
Winndooɓe ɓee mbiyi « asid formik e nder ƴiiƴam hollitii wonde ina moƴƴi no feewi ngam ƴeewde ko yaawi ñawu Alzheimer ». “Ƴeewndogol biomarker urine ngam anndude ñawu Alzheimer ina weeɓi, ina moƴƴi, ina foti waɗeede e ƴeewndorɗe cellal mawɓe.”
Wang, Y. e woɗɓe. (2022) Ƴeewndo njuɓɓudi asid formik e nder ƴiiƴam ngam wonde biomarker keso potɗo wonande ñawu Alzheimer. Keeri e nder neurobiyoloji duuɓi. Ɗemngal 2022.1046066.
Tags: duuɓi, ñawu Alzheimer, biomarkers, ƴiiƴam, ngaandi, ñawuuji ɓuuɓɗi, ñawuuji ɓuuɓɗi, compoññe, ŋakkere hakkille, ƴeewndorɗe, safrooɓe, formaldehiid, neurologie, tomogaraafi emision positron, wiɗto, tomogaraafi, ƴeewndo ƴiiƴam
E nder Pittcon 2023 to Filadelfi, Pennsylvanie, min yeewtidii e porfeseer Joseph Wang, keɓɗo njeenaari Ralph N. Adams hikka to bannge kemikal analitik, ko fayti e keewal karallaagal biosensor.
E nder ndee yeewtere, eɗen njeewta biopsie fooftere e no ɗum waawirta wonde kuutorgal nafoowal ngam janngude biomarkers ngam yiytude ñawu nguu ko yaawi e Mariana Leal, hooreejo fedde Owlstone Medical.
E nder ƴeewndo men SLAS US 2023, eɗen njeewta laboratuwaar janngo e no ɗum waawi nanndude e Luigi Da Via, hooreejo fedde ƴellitaare jarribooji GSK.
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