Laral yaajngal ɓuuɓngal, ngal funeeɓe e bakteriiji, ina wiyee « matrix extracellulaire » walla ECM, ina jogii mbaydi jelli, ina waɗi laral e kosam reenoowo. Kono e wiyde wiɗto sakkitiingo e jaaynde wiyeteende iScience, ngo duɗal jaaɓi-haaɗtirde Massachusetts Amherst yuɓɓini e ballondiral e duɗal jaaɓi-haaɗtirde Worcester, ECM won e mikroo-organismeeji ina waɗa gel tan so asid oksalik walla asiduuji goɗɗi koyɗi ina ngoodi. Sabu ECM ina jogii darnde mawnde e kala ko ina ummoo e reentaade antibiotik haa e tuubaaji ɓuuɓɗi e ɓuuɓnude kaɓirɗe safaara, faamde no mikroo-organismeeji ɗii kuutortoo laabi mum en gel ɓuuɓɗi ina jogii batte keewɗe e nguurndam men ñalnde kala.

Barry Goodell, porfeseer mikroo-biyoloji to duɗal jaaɓi-haaɗtirde Massachusetts Amherst, binnduɗo mawɗo winndannde ndee wiyi : « Miɗo yiɗi ECM-ji mikroo-biyoloji gila ko ɓooyi ». "Yimɓe ina keewi miijaade wonde ECM ko laylaytol yaajngol ngol alaa ko woni e mum, ngol reennata mikroo-organismeeji. Kono kadi ina waawi wonde jolngo ngam ñamri e enzim e nder e caggal geese mikroo-organismeeji."
Kosam ɗam ina waɗi golle keewɗe : ɓuuɓri mum firti ko mikroo-organismeeji keewɗi ina mbaawi jokkondirde ngam waɗde koloñaal walla « biofilm », so mikroo-organismeeji keewɗi mbaɗii ɗum, ina mbaawi uddude tuubaaji walla bonnude kaɓirɗe safaara.
Kono kadi kosam ɗam ina foti wonde ɓuuɓɗam : mikroo-organismeeji keewɗi ina njaltina enzimuuji keewɗi e mbayliigaaji goɗɗi e nder ECM, e nder huunde nde njiɗi ñaamde walla ɓuuɓnude (ko wayi no leɗɗe ɓole walla ƴiye ƴiye), caggal ɗuum, so enzim en timminii golle mum en, golle ɓuuɓgol – ina ngartira ñamri ndii e nder ECM.
Ɗum firti ko ECM wonaa tan laral reentorgal inert ; E goonga, no Goodell e gollodiiɓe mum kollitirta nii, ina wayi no mikroo-organismeeji ina njogii mbaawka jogaade doole ngam haɓaade ɓuuɓri ECM mum en, ɗum noon ina waawi jogaade doole mum. Hol no ɓe mbaɗata?
E nder funeeɓe, ɓuuɓri ndii ina nanndi e asid oksalik, asid organik keewɗo, keɓaaɗo e leɗɗe keewɗe, kadi, no Goodell e wondiiɓe mum njiyri nii, mikroo-organismeeji keewɗi ina nanndi e huutoraade asid oksalik mo ɓe njiylotoo ngam jokkondirde e laabi karbohidratuuji yaajɗi. waɗde huunde ɓuuɓnde. , ECM nannduɗo e jeli.
Kono nde kippu nguu ƴeewtindii, ɓe tawi ko asid oksalik wonaa tan wallita e feewnude ECM, kono kadi ina « reentoo » ɗum : so asid oksalik ɓeydiima e mikroobiiji ɗii e nder ɓuuɓri asid karbohidrat, ECM ina ɓeydoo ɓuuɓde. So ECM ɓeydiima ɓuuɓde, ina ɓeydoo haɗde molekule mawɗe naatde walla yaltude e mikroo, molekule tokoose ina keddii e wellitaare naatde e mikroo gila e weeyo e ko nanndi heen.
Ndee ɗoo yiytunde ina luulndii faamde ganndal aadaaji no mbaydiiji ceertuɗi ɗi funeeɓe e bakteriiji njaltinirta ɗii keɓirta tigi rigi e ɗeen tagooje tokoose e nder weeyo. Goodell e wondiiɓe mum mbiyi wonde e won e sahaaji, ina gasa tawa mikroo-organismeeji ɗii ɓuri tuugnaade ko e seerndude molekule tokoose no feewi ngam haɓtaade matriks walla tissu mo mikroo-organisme oo fawii e mum ngam wuurde walla heɓde ñawu nguu. Ɗum firti ko ɓuuɓnude molekule tokoose ina waawi kadi jogaade darnde mawnde e nder pathogenesis so tawii enzimuuji mawɗi mbaawaa rewde e mbaydi ekstraselulaar mikroobiyoŋ.
Goodell wiyi « ina wayi no ina woodi nokku hakkundeejo, ɗo mikroo-organismeeji mbaawi jogaade tolno asid ngam waawde huutoraade nokku keeriiɗo, jogaade won e molekule mawɗe, ko wayi no enzim, tawa ina addana molekule tokoose ɗee rewde e ECM e no feewi antibiotik, nde tawnoo ko heewi e ɗeen leɗɗe ina mbaɗi molekule mawɗe no feewi. Ko ngool baawngol huutoraade ina waawi wonde sabaabu foolde gooto e caɗeele mawɗe e nder safaara antimikrobiyaal, sibu huutoraade ECM ngam ɓeydude ɗum ɓuuɓde ina waawi ɓeydude kattanɗe antibiotik e antimikrobiyaal.

« So en mbaawii jogaade biyosintesis e seerndude asideeji tokoosi ko wayi no oksalaat e nder won e mikroobiiji, ndeen en mbaawa kadi jogaade ko naatata e nder mikroobiiji ɗii, ɗuum ina waawi addande en ɓurde safrude ñawuuji mikroobiiji keewɗi », wiyi Goodell.
E lewru desaambar 2022, ganndo ko faati e mikroo-biyoloji biyeteeɗo Yasu Morita heɓi dokkal ummoraade e Duɗal Ngenndiwal Cellal ngam wallitde wiɗtooji baɗɗiiɗi e darnde mum ngam ƴellitde safaaraaji kesi, ɓurɗi moƴƴude ngam safrude ñawu nguu.

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